Lymph node map

Class Activity: Lymph node map

 

Making Connections

 

Introduction: Immunology is a science that is replete with anatomical concepts, cell subsets, complicated, chemokine-directed cell movements, complex genetics, and interesting biochemistry, and so it is no wonder that our students too often get lost in the weeds. One useful classroom activity is to have them make visual maps that help them to make the connections between molecules, cells, functions, and factoids.

 

Resources: Students should be familiar with the material covered in Chapter 11 and have completed any reading assigned by the instructor. This exercise is one that should help them pull together material that they are already familiar with.

 

Instructions: First, draw (using ppt/adobe/paper) B-cell follicles, the T-cell zone, the medullary cords, and an HEV opening onto the diagram. For this part of the exercise, students can use their books and lecture notes as a resource but do not copy them.

 

Next, indicate the processes that occur in the lymph node over the course of lymphocyte activation, for example, dendritic cell (DC) antigen presentation to T cell; T-cell activation, T-cell and B-cell interaction; B-cell division; GC formation; creation of dark zone; creation of light zone; mantle zone formation; SHM; CSR; AID activity; antigen-mediated selection; formation of primary focus. Ask the students to work in groups to correctly place their labels. This is not a complete list of everything that should be included in this lymph node map.  Your map should include all topics that we have gone over in class. 

 

 

 

 

 

 

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